Keyword Analysis & Research: menthofuran synthase


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Is menthofuran synthase a cytochrome P450 monooxygenase?

Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene Arch Biochem Biophys. 2001 Jun 15;390(2):279-86.doi: 10.1006/abbi.2001.2378.

How is menthofuran synthesized?

Menthofuran can be synthesized from 5-methylcyclohexane-1,3-dione and allenyldimethylsulfonium bromide in two steps via a furannulation strategy consisting of enolate addition and rearrangement. Menthofuran is a metabolite of pulegone. Both in vitro and in vivo studies have found the pulegone metabolite menthofuran to be an inhibitor of CYP2A6.

Is menthofuran an inhibitor of CYP2A6?

Both in vitro and in vivo studies have found the pulegone metabolite menthofuran to be an inhibitor of CYP2A6. Menthofuran may deplete glutathione levels, leaving hepatocytes vulnerable to free radical damage.

Is menthofuran toxic to humans?

It is highly toxic and believed to be the primary toxin in pennyroyal responsible for its potentially fatal effects. After ingestion of menthofuran, it is metabolically activated to chemically reactive intermediates that are hepatotoxic. Menthofuran is produced biosynthetically from pulegone by the enzyme menthofuran synthase .


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